BackgroundThe discovery of biomarkers of ageing has led to the development of predictors of impending natural death and has paved the way for personalised estimation of the risk of death in the general population. This study intends to identify the ethical resources available to approach the idea of a long-lasting dying process and consider the perspective of death prediction. The reflection on human mortality is necessary but not sufficient to face this issue. Knowledge about death anticipation in clinical contexts allows (...) for a better understanding of it. Still, the very notion of prediction and its implications must be clarified. This study outlines in a prospective way issues that call for further investigation in the various fields concerned: ethical, psychological, medical and social.MethodsThe study is based on an interdisciplinary approach, a combination of philosophy, clinical psychology, medicine, demography, biology and actuarial science.ResultsThe present study proposes an understanding of death prediction based on its distinction with the relationship to human mortality and death anticipation, and on the analogy with the implications of genetic testing performed in pre-symptomatic stages of a disease. It leads to the identification of a multi-layered issue, including the individual and personal relationship to death prediction, the potential medical uses of biomarkers of ageing, the social and economic implications of the latter, especially in regard to the way longevity risk is perceived.ConclusionsThe present study work strives to propose a first sketch of what the implications of death prediction as such could be - from an individual, medical and social point of view. Both with anti-ageing medicine and the transhumanist quest for immortality, research on biomarkers of ageing brings back to the forefront crucial ethical matters: should we, as human beings, keep ignoring certain things, primarily the moment of our death, be it an estimation of it? If such knowledge was available, who should be informed about it and how such information should be given? Is it a knowledge that could be socially shared? (shrink)

Adult stem cell populations must coordinate their own maintenance with the generation of differentiated cell types to sustain organ physiology, in a spatially controlled manner and over long periods. Quantitative analyses of clonal dynamics have revealed that, in epithelia, homeostasis is achieved at the population rather than at the single stem cell level, suggesting that feedback mechanisms coordinate stem cell maintenance and progeny generation. In the central nervous system, however, little is known of the possible community processes underlying neural stem (...) cell maintenance. Recent work, in part based on intravital imaging made possible in the adult zebrafish, conclusively highlights that homeostasis in neural stem cell pools may rely on population asymmetry and long‐term spatiotemporal coordination of neural stem cell states and fates. These results suggest that neural stem cell assemblies in the vertebrate brain behave as self‐organized systems, such that the stem cells themselves generate their own intrinsic niche. (shrink)

Decades of tobacco control initiatives have turned public opinion against cigarette smoking. Smokers, once considered glamorous, are now stigmatized in domains including the workplace. Extant literature lacks scrutiny of smoker stigmatization and devaluation within the job selection process, and mechanisms that lead to such outcomes. Using an experimental design, we empirically examine initial reactions to job applicants’ smoking behaviors within two samples. We show that initial impressions are significantly worse when job applicants smoke versus do not in a store-based context. (...) Moreover, this effect occurs indirectly through perceived likelihood of engaging in counterproductive work behaviors, and is conditional upon respondents’ own attitudes towards smoking. These relationships—similar for customer service and inventory management jobs—are indicative of potential biases within the hiring process. Implications of these findings, and the moral dilemmas they raise around the treatment of smokers, are discussed from the ethical perspective of human resource management. (shrink)

In order to describe the logic of morality, "contractualist" philosophers have studied how individuals behave when they choose to follow their moral intuitions. These individuals, contractualists note, often act as if they have bargained and thus reached an agreement with others about how to distribute the benefits and burdens of mutual cooperation. Using this observation, such philosophers argue that the purpose of morality is to maximize the benefits of human interaction. The resulting "contract" analogy is both insightful and puzzling. On (...) one hand, it captures the pattern of moral intuitions, thus answering questions about human cooperation: why do humans cooperate? Why should the distribution of benefits be proportionate to each person's contribution? Why should the punishment be proportionate to the crime? Why should the rights be proportionate to the duties? On the other hand, the analogy provides a mere as-if explanation for human cooperation, saying that cooperation is "as if" people have passed a contract-but since they didn't, why should it be so? To evolutionary thinkers, the puzzle of the missing contract is immediately reminiscent of the puzzle of the missing "designer" of life-forms, a puzzle that Darwin's theory of natural selection essentially resolved. Evolutionary and contractualist theory originally intersected at the work of philosophers John Rawls and David Gauthier, who argued that moral judgments are based on a sense of fairness that has been naturally selected. In this book, Nicolas Baumard further explores the theory that morality was originally an adaptation to the biological market of cooperation, an arena in which individuals competed to be selected for cooperative interactions. In this environment, Baumard suggests, the best strategy was to treat others with impartiality and to share the costs and benefits of cooperation in a fair way, so that those who offered less than others were left out of cooperation while those who offered more were exploited by their partners. It is with this evolutionary approach that Baumard ultimately accounts for the specific structure of human morality. (shrink)

The picture of moral development defended by followers of Aristotle takes moral cultivation to be like playing a harp; one gets to be good by actually spending time playing a real instrument. On this view, we cultivate a virtue by doing the actions associated with that virtue. I argue that this picture is inadequate and must be supplemented by imaginative techniques. One can, and sometimes must, cultivate virtue without actually performing the associated actions. Drawing on strands in Buddhist philosophy, I (...) explain several methods of moral development that rely on imagination and visualization rather than overt action. These techniques are essential in cases where cultivating virtue the way one practices the harp is impossible. In particular, I focus on single-event virtues, first-time virtuous acts, and morally dangerous situations. (shrink)

Copyright ©2005–2010 All rights reserved. Jonathan Bennett [Brackets] enclose editorial explanations. Small ·dots· enclose material that has been added, but can be read as though it were part of the original text. Occasional •bullets, and also indenting of passages that are not quotations, are meant as aids to grasping the structure of a sentence or a thought. Every four-point ellipsis . . . . indicates the omission of a brief passage that seems to present more difficulty than it is worth. (...) Larger omissions are reported, between brackets, in normal-sized type. The numbering of the segments of each dialogue is Malebranche’s. (shrink)

(in press, under contract with MIT Press, accepted on June 30th, 2006). Attention, Information and Epistemic Perception. In Terzis, G. & Arp, R. (Eds) Information and the Living Systems: Essays in the Philosophy of Biology. The MIT Press. (14,000 words).

Sometimes physicians lie to third-party payers in order to grant their patients treatment they would otherwise not receive. This strategy, commonly known as gaming the system, is generally condemned for three reasons. First, it may hurt the patient for the sake of whom gaming was intended. Second, it may hurt other patients. Third, it offends contractual and distributive justice. Hence, gaming is considered to be immoral behavior. This article is an attempt to show that, on the contrary, gaming may sometimes (...) be a physician's duty. Under specific circumstances, gaming may be necessary from the viewpoint of the internal morality of medicine. Moreover, the objections against gaming are examples of what we call the idealistic fallacy, that is, the fallacy of passing judgments in a nonideal world according to ideal standards. Hence, the objections are inconclusive. Gaming is sometimes justified, and may even be required in the name of beneficence. (shrink)

It is commonly assumed that moral deliberation requires that the alternatives available in a choice situation are evaluatively comparable. This comparability assumption is threatened by claims of incomparability, which is often established by means of the small improvement argument (SIA). In this paper I argue that SIA does not establish incomparability in a stricter sense. The reason is that it fails to distinguish incomparability from a kind of evaluative indeterminacy which may arise due to the vagueness of the evaluative comparatives (...) ‘better than,’ ‘worse than,’ and ‘equally as good as.’. (shrink)

Whether on the theoretical level or by analyzing specific cases, this collection examines the different ways of experiencing and dealing with precarity. Its goal is to elucidate the uses of rhetoric so as to grasp to what extent the "minus" may (sometimes) represent a "plus".

In the past decade, experiments on altruistic punishment have played a central role in the study of the evolution of cooperation. By showing that people are ready to incur a cost to punish cheaters and that punishment help to stabilise cooperation, these experiments have greatly contributed to the rise of group selection theory. However, despite its experimental robustness, it is not clear whether altruistic punishment really exists. Here, I review the anthropological literature and show that hunter-gatherers rarely punish cheaters. Instead, (...) they avoid dealing with them and switch to other partners. I suggest that these data are better explained by individual selection, and in particular by partner choice models, in which individuals are in competition to be recruited by cooperative partners. I discuss two apparent problems for partner choice theories: large-scale cooperation and punishments in economic games. I suggest that rather than favouring group selection theory, these two phenomena provide evidence in favour of individual selection: (1) people produce large-scale cooperation through institutions in which punishment is not altruistic but rewarded on an individual basis; (2) punishment in experimental games can be explained without altruism and is indeed often better explained by individual interests. (shrink)

We provide a translation of Binet and Henri’s pioneering 1894 paper on the influence of suggestibility on memory. Alfred Binet is famous as the author who created the IQ test that bears his name, but he is almost unknown as the psychological investigator who generated numerous original experiments and fascinating results in the study of memory. His experiments published in 1894 manipulated suggestibility in several ways to determine effects on remembering. Three particular modes of suggestion were employed to induce false (...) recognitions: indirect suggestion by a preconceived idea; direct suggestion; and collective suggestion. In the commentary we suggest that Binet and Henri’s paper written over 115 years ago is still highly relevant even today. In particular, Binet’s legacy lives on in modern research on misinformation effects in memory, in studies of conformity, and in experiments on the social contagion of memory. (shrink)

_ _ Nick Bostrom popularizó y difundió las intuiciones básicas del movimiento transhumanista desde una perspectiva filosófica. Sin embargo, hoy en día sus ideas pueden considerarse auto contradictorias respecto a su pretensión de superar al humanismo. De hecho, se podría marcar el pensamiento de Bostrom como de ultrahumanista e incluso de materialista ingenuo (Gabriel 2018, 2019). No obstante, admitiendo que la filosofía progresa en cuanto disciplina, es posible identificar pensadores transhumanistas de segunda generación, es decir, pensadores transhumanistas capaces de comprender (...) los límites y presupuestos de las intuiciones presentadas por Bostrom. Consideraremos la actividad filosófica de James Hughes y Stefan L. Sorgner como un transhumanismo de segunda generación en tanto que sus propuestas de transhumanismo son coherentes respecto de sus propios presupuestos. El caso de Hughes refleja la posibilidad de un transhumanismo democrático y consistente con las exigencias morales de nuestros tiempos, mientras que el caso de Sorgner es una invitación a edificar un transhumanismo desde presupuestos no humanistas, a saber, desde la filosofía dinámica de Nietzsche. De este modo, el transhumanismo de segunda generación sería el producto de una reflexión respecto a la coherencia de las propias condiciones de posibilidad del transhumanismo. Palabras clave: Bostrom - Materialismo ingenuo - Filosofía Dinámica - Transhumanismo democrático - Filosofía del transhumanismo. (shrink)

We present a new proof of soundness/completeness of tableaux with respect to dialogical games in Classical First-Order Logic. As far as we know it is the first thorough result for dialogical games where finiteness of plays is guaranteed by means of what we call repetition ranks.

Punitive behaviours are often assumed to be the result of an instinct for punishment. This instinct would have evolved to punish wrongdoers and it would be the evidence that cooperation has evolved by group selection. Here, I propose an alternative theory according to which punishment is a not an adaptation and that there was no specific selective pressure to inflict costs on wrongdoers in the ancestral environment. In this theory, cooperation evolved through partner choice for mutual advantage. In the ancestral (...) environment, individuals were in competition to be recruited in cooperative ventures and it was vital to share the benefits of cooperation in a mutually advantageous manner. If individuals took a bigger share of the benefits, their partners would leave them for more interesting partners. If they took a smaller share, they would be exploited by their partners who would receive more than what they had contributed to produce. This competition led to the selection of a sense of fairness, a cognitive adaptation aiming to share equally the benefits of cooperation in order to attract partners. In this theory, punishment is not necessary for the evolution of cooperation. Punitive behaviours are only a way to restore fairness by compensating the victim or penalizing the culprit. Drawing on behavioural economics, legal anthropology, and cognitive psychology, I show that empirical data fit better with this framework than with the theory of group selection. When people punish, they do so to restore fairness rather than to help the group. (shrink)

High and low alexithymia scorers were confronted with a modified visual oddball task that allowed the study of categorical perception of emotional expressions on faces. Participants had to quickly detect a deviant (rare) morphed face that shared or did not share the same emotional expression as the frequent one. Expected categorical perception effects, which were also neurophysiologically indexed, showed that rare stimuli were detected faster if they depicted a different emotional expression compared to rare stimuli depicting the same emotional expression (...) than the frequent one. Even if no differences were observed at a behavioural level, high alexithymia scorers evidenced overall delayed neurophysiological responses in components related to the attentional processing of rare emotional faces. Moreover, the categorical perception effects for event-related components associated with the attentional processing were smaller in high alexithymia scorers and were even absent for anger. These results show that high alexithymia scorers present discrimination delays that are already observed at the attentional level. (shrink)

Las reflexiones que conforman el presente artículo intentan brindar un aporte a la cuestión de la naturaleza y de la problemática medioambiental desde el punto de vista de lo que denominaremos una filosofía del suelo. Se emprenderá dicha tarea a través de los planteos de una serie de autores y autoras pertenecientes a la contemporaneidad filosófica, que se han preocupado, en distinta medida y de modos muy diferentes, por la problemática de la tierra o el suelo: Donna Haraway, Tim Ingold (...) y Bruno Latour. Para esto, nos serviremos de una serie de elementos que extraeremos de la experiencia visual y táctil de las Líneas de Nazca, legado de nuestro pasado amerindio en el desierto peruano. El trabajo se dividirá en tres partes, dedicada cada una de ellas a explicitar ciertas reflexiones de los autores que puedan asociarse a una filosofía como la que pretendemos mentar. El enfoque priorizará los entrelazos entre los mismos y el desarrollo de elementos que nos permitan un entrecruzamiento de sus respectivas teorías. (shrink)

Written seven years after publication of his Search after Truth, Malebranche's Treatise on Ethics develops a detailed, experimental science of ethics in two parts - the ethics of virtue and the ethics of duty.

In the literature on medical ethics, it is generally admitted that vulnerable persons or groups deserve special attention, care or protection. One can define vulnerable persons as those having a greater likelihood of being wronged – that is, of being denied adequate satisfaction of certain legitimate claims. The conjunction of these two points entails what we call the Special Protection Thesis. It asserts that persons with a greater likelihood of being denied adequate satisfaction of their legitimate claims deserve special attention, (...) care or protection. Such a thesis remains vague, however, as long as we do not know what legitimate claims are. This article aims at dispelling this vagueness by exploring what claims we have in relation to health care – thus fleshing out a claim-based conception of vulnerability. We argue that the Special Protection Thesis must be enriched as follows: If individual or group X has a greater likelihood of being denied adequate satisfaction of some of their legitimate claims to physical integrity, autonomy, freedom, social provision, impartial quality of government, social bases of self-respect or communal belonging, then X deserves special attention, care or protection. With this improved understanding of vulnerability, vulnerability talk in healthcare ethics can escape vagueness and serve as an adequate basis for practice. (shrink)

We introduce a logic specifically designed to support reasoning about social choice functions. The logic includes operators to capture strategic ability, and operators to capture agent preferences. We establish a correspondence between formulae in the logic and properties of social choice functions, and show that the logic is expressively complete with respect to social choice functions, i.e., that every social choice function can be characterised as a formula of the logic. We prove that the logic is decidable, and give a (...) complete axiomatization. To demonstrate the value of the logic, we show in particular how it can be applied to the problem of determining whether a social choice function is strategy-proof. (shrink)

Après avoir restitué le mouvement du commentaire sartrien, l'Auteur le confronte aux textes cartésiens quant aux rapports de la liberté et de la vérité, de la liberté et de la négativité, de la liberté et de la contingence. Le problème est de savoir si Descartes n'avait pas reconnu dans l'homme la liberté que Satire ne croit chez lui trouver qu'en Dieu. Nachdem der Verfasser den Weg und den Takt von Sartres Auslegung wiedergegelsen hat stellt er sie gegenüber mit den cartesianischen (...) Schriften was die Verbindung von Freiheit und Wahrheit, von Freiheit und Werneinung, von Freiheit und zufälliger Möglichkeit anbelangt. Die Frage stellt sich zu wissen ob Descartes die Freiheit, die Sartre bei ihm nur in Gott findet, nicht auch im Mensch erkannt hat. (shrink)

Mais en même temps, tous ses familiers en témoignent, Socrate était un sorcier. Comme le chaman dont Lévi-Strauss décrit l'efficacité symbolique, sa parole était guérisseuse. " Comme il nous a guéris ! " s'émerveille Phédon.

Lorsque Descartes parvient à la fameuse certitude que « je pense, donc je suis », quel est ce je qui découvre l'évidence de son être, dans l'instant même où il n'y a plus aucun être qu'il n'ait rendu douteux? Fallait-il vraiment, comme l'en raille Gassendi, la mise en œuvre d'un aussi grand appareil pour n'en arriver qu'à une aussi banale découverte? Si, portant sur l'infinité des créatures, le doute manifeste par le fait l'exercice d'une volonté infinie, d'où vient que Descartes (...) n'ait pourtant explicitement affirmé cette infinité dans aucune de ses œuvres, mais seulement une fois dans une lettre de 1639? Pourquoi le Discours de la méthode constitue-t-il une sorte de césure dans le développement de l'entreprise cartésienne? Pourquoi l'exposé d'une morale provisoire, qui ne sera d'ailleurs repris dans aucun autre ouvrage ultérieur, y vient-il interrompre celui de sa doctrine et le récit de ses découvertes? Pourquoi Descartes ne donne-t-il plus ensuite qu'à la métaphysique un temps qu'il s'y était promis de consacrer tout à sa physique? Comment est-il possible que l'homme lui paraisse capable de jouir « dès cette vie » de « la parfaite félicité », et de ne devoir qu'à l'exercice de sa liberté une « béatitude naturelle »? Serait-ce que la générosité consiste dans l'expérience métaphysique de l'infinité même de notre liberté?C'est à ces questions que tentent de répondre les études ici réunies, qui toutes cherchent à élucider le statut de la liberté dans la métaphysique cartésienne. (shrink)

Dieu, le temps, la liberte: trois manieres de poser le probleme des rapports du fini et de l'infini. Comment un etre fini peut-il etre tellement hante par l'idee de l'infini, qu'elle soit la plus originaire et l'horizon de toutes ses pensees? Si Dieu a tout cree sans ordre ni raison, l'infinite de sa puissance n'est-elle pas son unique perfection? Comment une creature finie peut-elle desirer acquerir les perfections infinies qu'elle concoit en Dieu sans s'assigner ainsi une tache infinie? Pour deduire (...) l'infinite des verites creees du petit nombre d'idees et d'axiomes qui sont innes a son entendement, ne lui faudrait-il pas un temps infini? Mais, faute d'en disposer jamais, peut-elle s'eprouver assignee a une tache infinie sans eprouver ce mauvais infini comme l'echec d'un perpetuel inachevement? En confrontant les analyses de Descartes a celles de Malebranche et de Leibniz, c'est a ces problemes que les six etudes ici reunies tentent d'apporter quelque lumiere. (shrink)

Recently, swimming-style colour synaesthesia was introduced as a new form of synaesthesia. A synaesthetic Stroop test was used to establish its genuineness. Since Stroop interference can occur for any type of overlearned association, in the present study we used a modified Stroop test and psychophysiological synaesthetic conditioning to further establish the genuineness of this form of synaesthesia. We compared the performance of a swimming-style colour synaesthete and a control who was trained on swimming-style colour associations. Our results showed that behavioural (...) aspects of swimming-style colour synaesthesia can be mimicked in a trained control. Importantly, however, our results showed a psychophysiological conditioning effect for the synaesthete only. We discuss the theoretical relevance of swimming-style colour synaesthesia according to different models of synaesthesia. We conclude that swimming-style colour synaesthesia is a genuine form of synaesthesia, can be mimicked behaviourally in non-synaesthetes, and is best explained by a re-entrant feedback model. (shrink)